Why waking up between 2am and 3am could actually mean something serious

Dr. Berg says there are strategies that may help reduce cortisol levels while sleeping and prevent those early-morning awakenings. One of the most important, he says, is magnesium.

A lack of magnesium can cause muscle tightness, cramps, and heightened cortisol. He explained that stiffness in the back or leg cramps—especially when pointing the toes—can be signs of deficiency.

Magnesium also supports muscle relaxation, calms the nervous system, and can help reduce anxiety and irritability. Dr. Berg recommends taking magnesium supplements in the evening before bed

He added that magnesium levels in the body are typically lowest around 6 a.m., which may help explain why certain medical issues—such as heart attacks, strokes, and restless leg syndrome—often occur in the early morning hours

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